Common Use

Analgin is used for pain syndromes of different origins:

• Headache and migraine pain
• Neuralgia
• Myalgia
• Toothache
• Oligomenorrhea
• Chorea
• Rheumatism
• Radiculitis
• Fever caused by infectious and inflammatory diseases

Additionally, Analgin is used in surgical practice to eliminate postoperative pain. For renal and biliary colic, it is effective in combination with antispasmodic drugs.

Pharmacologic Effect

Analgin is a derivative of pyrazolone and is characterized by:

• Pronounced analgesic, antipyretic, and minor anti-inflammatory actions
• Anti-inflammatory effect due to inhibition of prostaglandin production
• Antipyretic effect by reducing the production and release of substances affecting heat production
• Analgesic action by inhibiting cyclooxygenase and the synthesis of prostaglandins, blocking pain impulses, increasing pain threshold, and reducing brain response to pain
• Antispasmodic effect on smooth muscles of the biliary and urinary tract

Instructions for Use

Analgin should be taken:

• Orally, intramuscularly, or intravenously as prescribed by a doctor
• Dosage depends on pain intensity, fever, and individual response
• Tablets should be swallowed whole with a sufficient amount of liquid (e.g., a glass of water)
• Dosage for adults: 0.25-0.5 g 2-3 times a day; for rheumatism: up to 1 g 3 times a day
• Children: 5-10 mg/kg 3-4 times a day
• Intramuscularly or intravenously (for severe pain): Adults: 1-2 ml of 50% or 25% solution 2-3 times a day, no more than 2 g per day. Children: 0.1-0.2 ml of 50% solution or 0.2-0.4 ml of 25% solution per 10 kg of body weight
• Higher doses: Adults: single - 1 g, daily - 3 g; intramuscularly/intravenously: single - 1 g, daily - 2 g
• Avoid high doses with reduced renal or hepatic function. Long-term use requires regular blood monitoring

Contraindications

Contraindications for Analgin use include:

• Hypersensitivity to metamizole sodium or other pyrazolone derivatives
• Hematopoietic suppression (e.g., agranulocytosis, neutropenia, leukopenia)
• Anemia, including hereditary hemolytic anemia associated with glucose-6-phosphate dehydrogenase deficiency
• Asthma caused by acetylsalicylic acid
• Renal and/or liver failure
• Pregnancy
• Breastfeeding period
• Age under 15 years

In pediatric practice, tablets are used from age ten, suppositories from one year. Intramuscular administration is not recommended for children under three months or weighing less than five kilograms. Intravenous administration is contraindicated for children aged three to eleven months.

Side Effects

Possible side effects of Analgin include:

• Urinary System: Renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red
• Blood-Forming Organs: Agranulocytosis, leukopenia, thrombocytopenia
• Allergic Reactions: Urticaria (including conjunctiva and mucous membranes), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock
• Other: Decrease in blood pressure; local reactions such as infiltrates at the injection site with intramuscular injection